Results The mean particle size of microspheres was observed to be between 6.9 to 9.5 µm
and the maximum particle size was around 50 µm. In vivo studies of the selected batches
indicated lower level of serum cholesterol compared to the marketed tablet at the same dose
but was not significant.

Lovastatin is an antihyperlipidemic agent which has low bioavailability due to the extensive
first pass metabolism. It was sought to increase gastric retention of lovastatin by
development of a sustained release gastroretentive drug delivery system leading to reduced
fluctuation in the plasma concentration and improved bioavailability. Floating microspheres
were prepared by emulsion solvent diffusion technique, using various polymers and their
blends. The in vitro performance was evaluated for drug-polymer compatibility, percent yield …