Improvement of the Cramer classification for oral exposure using the database TTC RepDose–a strategy description
I Tluczkiewicz, HE Buist, MT Martin… - Regulatory Toxicology …, 2011 - Elsevier
The present report describes a strategy to refine the current Cramer classification of the TTC
concept using a broad database (DB) termed TTC RepDose. Cramer classes 1–3 overlap to
some extent, indicating a need for a better separation of structural classes likely to be toxic,
moderately toxic or of low toxicity. Groups of structurally similar compounds of high toxicity in
Cramer class 1 and of moderate to low toxicity in Cramer class 3 were identified and
reassigned to the appropriate Cramer class according to their observed toxicological …
concept using a broad database (DB) termed TTC RepDose. Cramer classes 1–3 overlap to
some extent, indicating a need for a better separation of structural classes likely to be toxic,
moderately toxic or of low toxicity. Groups of structurally similar compounds of high toxicity in
Cramer class 1 and of moderate to low toxicity in Cramer class 3 were identified and
reassigned to the appropriate Cramer class according to their observed toxicological …
以上显示的是最相近的搜索结果。 查看全部搜索结果