In Vitro, In Vivo, and In Silico Studies of Cumanin Diacetate as a Potential Drug against Trypanosoma cruzi Infection
A Sanchez Alberti, MF Beer, N Cerny, AE Bivona… - ACS …, 2021 - ACS Publications
The sesquiterpene lactones cumanin, helenalin, and hymenin and their semisynthetic
derivatives were evaluated against Trypanosoma cruzi epimastigotes. The cytotoxicity of the
compounds was evaluated on murine splenocytes. Cumanin diacetate was one of the most
active and selective compounds [IC50= 3.20±0.52 μg/mL, selectivity index (SI)= 26.0]. This
sesquiterpene lactone was selected for its evaluation on trypomastigote and amastigote
forms of the parasite. The diacetylated derivative of cumanin showed moderate activity on …
derivatives were evaluated against Trypanosoma cruzi epimastigotes. The cytotoxicity of the
compounds was evaluated on murine splenocytes. Cumanin diacetate was one of the most
active and selective compounds [IC50= 3.20±0.52 μg/mL, selectivity index (SI)= 26.0]. This
sesquiterpene lactone was selected for its evaluation on trypomastigote and amastigote
forms of the parasite. The diacetylated derivative of cumanin showed moderate activity on …
In Vitro, in vivo, and in silico studies of cumanin diacetate as a potential drug against trypanosoma cruzi infection
AS Alberti, MF Beer, N Cerny, AE Bivona… - ACS …, 2021 - pmc.ncbi.nlm.nih.gov
The sesquiterpene lactones cumanin, helenalin, and hymenin and their semisynthetic
derivatives were evaluated against Trypanosoma cruzi epimastigotes. The cytotoxicity of the
compounds was evaluated on murine splenocytes. Cumanin diacetate was one of the most
active and selective compounds [IC50= 3.20±0.52 μg/mL, selectivity index (SI)= 26.0]. This
sesquiterpene lactone was selected for its evaluation on trypomastigote and amastigote
forms of the parasite. The diacetylated derivative of cumanin showed moderate activity on …
derivatives were evaluated against Trypanosoma cruzi epimastigotes. The cytotoxicity of the
compounds was evaluated on murine splenocytes. Cumanin diacetate was one of the most
active and selective compounds [IC50= 3.20±0.52 μg/mL, selectivity index (SI)= 26.0]. This
sesquiterpene lactone was selected for its evaluation on trypomastigote and amastigote
forms of the parasite. The diacetylated derivative of cumanin showed moderate activity on …
以上显示的是最相近的搜索结果。 查看全部搜索结果