In this chapter, we review the current state of in silico tools for lung deposition applications
and discuss how knowledge gathered from recent studies can be purposefully leveraged to
design efficient hybrid multiscale lung models. We firstly address the different roles of in
silico methods when applied to the human lung airways. We then discuss the variability of
airflow and particle transport regimes in different regions of the human lung and how in silico
methods are employed in each case. In the next section, we focus on numerical aspects …