In vitro and in vivo antifilarial activity evaluation of 3, 6-epoxy [1, 5] dioxocines: a new class of antifilarial agents
Bioorganic & medicinal chemistry letters, 2012•Elsevier
A series of 3, 6-epoxy [1, 5] dioxocines were synthesized and evaluated for their antifilarial
activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-
periodic strain) in vitro. Out of these, six compounds (4a–f) possessed improved in vitro anti-
filarial activity and examples 4d and 4f were also found to be active in the in vivo
experiments. These results demonstrate that 3, 6-epoxy [1, 5] dioxocines exhibits potent
antifilarial activity and might be developed into a new class of antifilarial drug.
activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-
periodic strain) in vitro. Out of these, six compounds (4a–f) possessed improved in vitro anti-
filarial activity and examples 4d and 4f were also found to be active in the in vivo
experiments. These results demonstrate that 3, 6-epoxy [1, 5] dioxocines exhibits potent
antifilarial activity and might be developed into a new class of antifilarial drug.
A series of 3,6-epoxy [1,5]dioxocines were synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro. Out of these, six compounds (4a–f) possessed improved in vitro anti-filarial activity and examples 4d and 4f were also found to be active in the in vivo experiments. These results demonstrate that 3,6-epoxy [1,5]dioxocines exhibits potent antifilarial activity and might be developed into a new class of antifilarial drug.
Elsevier
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