[HTML][HTML] In vitro anti-candida activity of the hydroalcoholic extracts of heracleum persicum fruit against phatogenic candida species
BS Nejad, M Rajabi, AZ Mamoudabadi… - Jundishapur journal of …, 2014 - ncbi.nlm.nih.gov
BS Nejad, M Rajabi, AZ Mamoudabadi, M Zarrin
Jundishapur journal of microbiology, 2014•ncbi.nlm.nih.govBackground: Nowadays Candida albicans has become resistant to the toxic and expensive
commercial anti-Candida drugs. Therefore, investigation for new anti-fungal agents is
necessary. Objectives: The purpose of this survey was to investigate the in vitro anti-
Candida activity of the hydroalcoholic extracts of Heracleum persicum fruit. Materials and
Methods: The plant ingredients were extracted using 80% ethanol and the extract was
screened against 46 isolated pathogenic Candida species such as C. albicans, C. glabrata …
commercial anti-Candida drugs. Therefore, investigation for new anti-fungal agents is
necessary. Objectives: The purpose of this survey was to investigate the in vitro anti-
Candida activity of the hydroalcoholic extracts of Heracleum persicum fruit. Materials and
Methods: The plant ingredients were extracted using 80% ethanol and the extract was
screened against 46 isolated pathogenic Candida species such as C. albicans, C. glabrata …
Abstract
Background:
Nowadays Candida albicans has become resistant to the toxic and expensive commercial anti-Candida drugs. Therefore, investigation for new anti-fungal agents is necessary.
Objectives:
The purpose of this survey was to investigate the in vitro anti-Candida activity of the hydroalcoholic extracts of Heracleum persicum fruit.
Materials and Methods:
The plant ingredients were extracted using 80% ethanol and the extract was screened against 46 isolated pathogenic Candida species such as C. albicans, C. glabrata and C. tropicalis by agar well diffusion method.
Results:
The minimum inhibitory concentration (MIC) values at 24 and 48 hours were 0.625-20 µg/µL for C. albicans, 0.625-40 µg/µL for C. glabrata, and 5.0-20 µg/µL for C. tropicalis.
Conclusions:
The results of this survey confirmed that tested plant extract had a potential anti-Candida activity. Hence, it is suggested to isolate and identify its active compounds in future.
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