In vitro inhibitory effect of aflatoxin B1 on acetylcholinesterase activity in mouse brain
MF Cometa, P Lorenzini, S Fortuna, MT Volpe… - Toxicology, 2005 - Elsevier
Growing concern on the problem of mycotoxins in the alimentary chain underlines the need
to investigate the mechanisms explaining the cholinergic effects of aflatoxin B1 (AFB1). We
examined the effect of AFB1, a mycotoxin produced by Aspergillus flavus, on mouse brain
acetylcholinesterase (AChE) and specifically on its molecular isoforms (G1 and G4) after in
vitro exposure. AFB1 (from 10− 9 to 10− 4M), inhibited mouse brain AChE activity (IC50=
31.6× 10− 6M) and its G1 and G4 molecular isoforms in a dose-dependent manner …
to investigate the mechanisms explaining the cholinergic effects of aflatoxin B1 (AFB1). We
examined the effect of AFB1, a mycotoxin produced by Aspergillus flavus, on mouse brain
acetylcholinesterase (AChE) and specifically on its molecular isoforms (G1 and G4) after in
vitro exposure. AFB1 (from 10− 9 to 10− 4M), inhibited mouse brain AChE activity (IC50=
31.6× 10− 6M) and its G1 and G4 molecular isoforms in a dose-dependent manner …