In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
S Noonberg, AC Hunt - Biotechnology Advances, 1997 - elibrary.ru
The present invention encompasses improved methods and materials for the delivering of
antisense, triplex, and/or ribozyme oligonucleotides intracellularly, and RNA polymerase III-
based constructs termed oligonucleotide generators to accomplish the delivery of
oligonucleotides. Also encompassed by the present invention are methods for screening
oligonucleotide sequences that are candidates for triplex formation.
antisense, triplex, and/or ribozyme oligonucleotides intracellularly, and RNA polymerase III-
based constructs termed oligonucleotide generators to accomplish the delivery of
oligonucleotides. Also encompassed by the present invention are methods for screening
oligonucleotide sequences that are candidates for triplex formation.
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