In-Silico molecular screening of natural compounds as a potential therapeutic inhibitor for Methicillin-resistant Staphylococcus aureus inhibition
Methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening superbug causing
infectious diseases such as pneumonia, endocarditis, osteomyelitis, etc. Conventional
antibiotics are ineffective against MRSA infections due to their resistance mechanism
against the antibiotics. The Penicillin Binding Protein (PBP2a) inhibits the activity of
antibiotics by hydrolyzing the β-lactam ring. Thus, alternate treatment methods are needed
for the treatment of MRSA infections. Natural bioactive compounds exhibit good inhibition …
infectious diseases such as pneumonia, endocarditis, osteomyelitis, etc. Conventional
antibiotics are ineffective against MRSA infections due to their resistance mechanism
against the antibiotics. The Penicillin Binding Protein (PBP2a) inhibits the activity of
antibiotics by hydrolyzing the β-lactam ring. Thus, alternate treatment methods are needed
for the treatment of MRSA infections. Natural bioactive compounds exhibit good inhibition …
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