Incorporation of fluorescein conjugated function-spacer-lipid constructs into the red blood cell membrane facilitates detection of labeled cells for the duration of ex-vivo …

KK Ki, RL Flower, HM Faddy, MM Dean - Journal of Immunological …, 2016 - Elsevier
The contribution of ex-vivo storage duration of packed red blood cells (PRBC) to patient
outcomes and transfusion-related immunomodulation (TRIM) remains a broadly debated
area in transfusion medicine. Kode™ Technology with fluorescein conjugated function-
spacer-lipid (FSL-FLRO4) constructs is a tool that can aid in-vitro visualization and tracking
of red blood cells (RBC) during routine storage. FSL-FLRO4 is incorporated into the RBC
membrane without altering cell function. In this study, we explore the suitability of this …
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