Increased circulating CD31+/CD42− microparticles are associated with impaired systemic artery elasticity in healthy subjects
JM Wang, YJ Huang, Y Wang, MG Xu… - American journal of …, 2007 - academic.oup.com
JM Wang, YJ Huang, Y Wang, MG Xu, LC Wang, SM Wang, J Tao
American journal of hypertension, 2007•academic.oup.comBackground: Impaired artery elasticity has been found in various pathological conditions
related to endothelial dysfunction. Recently, CD31+/CD42− microparticles (MPs) emerged
as a marker of endothelial injury. Whether CD31+/CD42− MPs, generated under
physiological conditions, are correlated with artery properties has not been reported.
Methods: We evaluated brachia–ankle pulse-wave velocity (baPWV)(n= 76) and C1 large-
artery and C2 small-artery elasticity indices (n= 56), using noninvasive devices for pulse …
related to endothelial dysfunction. Recently, CD31+/CD42− microparticles (MPs) emerged
as a marker of endothelial injury. Whether CD31+/CD42− MPs, generated under
physiological conditions, are correlated with artery properties has not been reported.
Methods: We evaluated brachia–ankle pulse-wave velocity (baPWV)(n= 76) and C1 large-
artery and C2 small-artery elasticity indices (n= 56), using noninvasive devices for pulse …
Background
Impaired artery elasticity has been found in various pathological conditions related to endothelial dysfunction. Recently, CD31+/CD42− microparticles (MPs) emerged as a marker of endothelial injury. Whether CD31+/CD42− MPs, generated under physiological conditions, are correlated with artery properties has not been reported.
Methods
We evaluated brachia–ankle pulse-wave velocity (baPWV) (n = 76) and C1 large-artery and C2 small-artery elasticity indices (n = 56), using noninvasive devices for pulse-wave analysis in a group of healthy persons. The number of circulating CD31+/CD427− MPs (n = 76) was measured by flow cytometric analysis.
Results
Circulating CD31+/CD42− MPs were positively correlated with values of baPWV (r = 0.371, P = .008) and with C1 large-artery and C2 small-artery elasticity indices (r = −0.294, P = .037; and r = −0.310, P = .027, respectively). Multivariate analysis identified CD31+/CD42− MPs as potent contributors to the development of impaired systemic artery elasticity.
Conclusions
The level of circulating CD31+/CD42− MPs, an important biomarker of dysfunctional endothelium and vascular injury, is closely associated with impaired systemic artery elasticity in healthy subjects. The present study suggests that CD31+/CD42− MPs may be a novel surrogate marker for the clinical evaluation of vascular damage. Am J Hypertens 2007;20: 957–964 © 2007 American Journal of Hypertension, Ltd.
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