Induction of NGF by isoproterenol, 4-methylcatechol and serum occurs by three distinct mechanisms
S Carswell, EK Hoffman, K Clopton-Hartpence… - Molecular brain …, 1992 - Elsevier
Evidence is provided that isoproterenol, 4-methylcatechol and serum induce NGF by three
separate mechanisms. Isoproterenol and 4-methyl-catechol induced NGF and NGF mRNA
in mouse fibroblast L929 cells in either the presence or absence of serum. Propranolol
prevented NGF induction by isoproterenol, but not by 4-methylcatechol or serum. All
possible combinations of these inducers resulted in additive increases in the levels of NGF
and NGF mRNA.
separate mechanisms. Isoproterenol and 4-methyl-catechol induced NGF and NGF mRNA
in mouse fibroblast L929 cells in either the presence or absence of serum. Propranolol
prevented NGF induction by isoproterenol, but not by 4-methylcatechol or serum. All
possible combinations of these inducers resulted in additive increases in the levels of NGF
and NGF mRNA.
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