Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans
E Derhovanessian, AB Maier… - Journal of General …, 2011 - microbiologyresearch.org
Human cytomegalovirus (CMV) establishes persistent, usually asymptomatic, infection in
healthy people. Because CMV infection is associated with the presence of lower proportions
of peripheral naïve CD8+ T-cells and a higher fraction of late-differentiated CD8+ cells,
commonly taken as biomarkers of age-associated compromised adaptive immunity
('immunosenescence'), we asked whether chronic exposure to any persistent virus mediates
these effects. Herpes simplex virus (HSV) is also a widespread herpesvirus that establishes …
healthy people. Because CMV infection is associated with the presence of lower proportions
of peripheral naïve CD8+ T-cells and a higher fraction of late-differentiated CD8+ cells,
commonly taken as biomarkers of age-associated compromised adaptive immunity
('immunosenescence'), we asked whether chronic exposure to any persistent virus mediates
these effects. Herpes simplex virus (HSV) is also a widespread herpesvirus that establishes …
Infection with Cytomegalovirus but not Herpes Simplex Virus induces the accumulation of late differentiated “senescent” T-cells in humans (39.13)
Infection with the persistent reactivating human cytomegalovirus (CMV) is associated with an
age-associated increasing accumulation of late-differentiated CD8+ T-cells even in
asymptomatic healthy carriers. It has been postulated that chronic exposure to any
repetitively stimulating antigen (” chronic antigenic stress”) will have similar effects. Here, we
have analyzed CMV and HSV infection status in the general population. Detailed analysis of
T-cell subsets was performed using 10-colour flow cytometry in 100 individuals aged 40-80 …
age-associated increasing accumulation of late-differentiated CD8+ T-cells even in
asymptomatic healthy carriers. It has been postulated that chronic exposure to any
repetitively stimulating antigen (” chronic antigenic stress”) will have similar effects. Here, we
have analyzed CMV and HSV infection status in the general population. Detailed analysis of
T-cell subsets was performed using 10-colour flow cytometry in 100 individuals aged 40-80 …
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