Inflaming the brain with iron

PJ Urrutia, DA Bórquez, MT Núñez - Antioxidants, 2021 - mdpi.com
… in brain iron levels and oxidative stress in a systemic iron overload rat model [151] and
reduces dopamine neuronal loss and limits ironiron entry into the brain and diminishes iron

Inflammation-induced iron transport and metabolism by brain microglia

RC McCarthy, JC Sosa, AM Gardeck, AS Baez… - Journal of Biological …, 2018 - ASBMB
… Moreover, LPS increased heme oxygenase-1 (HO1) expression in IMG cells, and iron … -iron
pool. Together, this evidence indicates that brain microglia preferentially acquire iron from Tf …

[PDF][PDF] Inflaming the Brain with Iron. Antioxidants 2021, 10, 61

PJ Urrutia, DA Bórquez, MT Núñez - 2021 - medicina.udp.cl
… in brain iron levels and oxidative stress in a systemic iron overload rat model [151] and
reduces dopamine neuronal loss and limits ironiron entry into the brain and diminishes iron

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration

HH Andersen, KB Johnsen, T Moos - Cellular and Molecular Life Sciences, 2014 - Springer
… -containing inflammatory cells, including microglia and macrophages, are consistently
present in inflamed brain tissue, suggesting the latter as sources for both iron donation and …

Inflaming the brain with iron

PJ Urrutia Vargas, DA Bórquez, MT Núñez González - 2021 - repositorio.uchile.cl
… in brain iron levels and oxidative stress in a systemic iron overload rat model [151] and
reduces dopamine neuronal loss and limits ironiron entry into the brain and diminishes iron

Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons

MS Thomsen, MV Andersen, PR Christoffersen… - Neurobiology of …, 2015 - Elsevier
… In the inflamed SNpr, the individual ED1 immunoreactive brain macrophages displayed signs
of amoeboid cells probably reflecting their nature as monocytes that have migrated into the …

In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation

T Tang, A Valenzuela, F Petit, S Chow… - Contrast Media & …, 2018 - Wiley Online Library
… inflammation in the brain produced endogenous contrast … of inflamed brains was tested in
the groups 2 and 3. Group 4 was designed to evaluate the impact of SDIO on the normal brain. …

The involvement of iron in traumatic brain injury and neurodegenerative disease

M Daglas, PA Adlard - Frontiers in neuroscience, 2018 - frontiersin.org
… This heightened increase in brain iron levels can potentiate oxidative stress and neurotoxicity
(as extensively covered in this review), and therefore is a possible explanation for the …

Iron and neurodegeneration in the multiple sclerosis brain

S Hametner, I Wimmer, L Haider… - Annals of …, 2013 - Wiley Online Library
… human brain with age. Our study focused on nonheme iron distribution and the expression
of the iron‐… in relation to oxidative damage in the brain tissue of 33 MS and 30 control cases. …

In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide

MA McAteer, NR Sibson, C von Zur Muhlen… - Nature medicine, 2007 - nature.com
… Here we report in vivo detection of VCAM-1 in acute brain inflammation, by magnetic …
Antibody-conjugated microparticles carrying a large amount of iron oxide provide potent, …