Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease
AD Wahner, JS Sinsheimer, JM Bronstein… - Archives of …, 2007 - jamanetwork.com
Background The proinflammatory cytokines tumor necrosis factor α (TNF-α) and IL-1β
(interleukin 1β) have a role in neuroinflammation, and functional polymorphisms in theTNF-
αandIL-1βgenes may affect susceptibility to Parkinson disease (PD). Objective To
investigate whether functional DNA polymorphisms of theTNF-αandIL-1βgenes affect the
risk of PD. Design Population-based case-control study. Setting Three rural California
counties (Fresno, Tulare, and Kern). Participants Two hundred eighty-nine incident …
(interleukin 1β) have a role in neuroinflammation, and functional polymorphisms in theTNF-
αandIL-1βgenes may affect susceptibility to Parkinson disease (PD). Objective To
investigate whether functional DNA polymorphisms of theTNF-αandIL-1βgenes affect the
risk of PD. Design Population-based case-control study. Setting Three rural California
counties (Fresno, Tulare, and Kern). Participants Two hundred eighty-nine incident …
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