The glucocorticoid receptor (GR) is a nuclear receptor that controls critical biological
processes by regulating the transcription of specific genes. GR transcriptional activity is
modulated by a series of ligands and coenzymes, where a ligand can act as an agonist or
antagonist. GR agonists, such as the glucocorticoids dexamethasone (DEX) and
prednisolone, are widely prescribed to patients with inflammatory and autoimmune
diseases. DEX is also used to induce osteogenic differentiation in vitro. Recently, it has been …