Conventional functional connectivity (FC) analysis of fMRI data derives a single
measurement from the entire scan, generally several minutes in duration, which neglects the
brain's dynamic behaviour and potentially loses important temporal information. Short-
interval dynamic FC is an attractive proposition if methodological issues can be resolved
and the approach validated. This was addressed in two ways; firstly we assessed FC of the
posterior cingulate cortex (PCC) node of the default mode network (DMN) using differing …

37 Functional connectivity (FC) can be measured using fMRI as the tem-38 poral correlation
of low-frequency (b0. 1 Hz) blood-oxygenation-level-39 dependent (BOLD) signal
fluctuations from separate brain regions 40 (Friston, 2011). These brain regions collectively
form intrinsically 41 connected networks (ICNs), which are believed to underpin cognitive 42
function (Hellyer et al., 2014; Stevens and Spreng, 2014). As such, FC 43 has increasingly
been used to characterise ICNs in the healthy and 44 pathological brain (Fox and Greicius …