This paper presents the effects of cutting speed, nanoparticles’ size, and their concentration in water-based TiO₂ nanofluid on the magnitude of tool flank wear and tool wear rate. The types of nanoparticles and base fluid, nanoparticle size, and nanoparticle concentration can affect the tribological and heat transfer properties of nanofluids, and thereupon, these parameters can affect the cutting forces and temperatures during the metal cutting process, thereby affecting tool wear and nanolubricant consumption. According to the achieved results, with an increase in the size of nanoparticles from 10 to 50 nm, the average decrease in cutting tool flank wear reduces from 46.2% to 34.8%.