An experiment was conducted during the rainy season (kharif) of 2016 at Barapani, Meghalaya, to study the in fluence of promising rice (Oryza sativa L.) varieties and nutrient-management practices on plant nutrient acquisi tion and soil fertility. The experiment was laid out in split-plot design, replicated thrice, consisting 12 treatment combinations, viz. 4 nutrient-management practices [100% organic, 100% inorganic recommended dose of fertil izer (RDF), integrated nutrient management (INM) (50% RDF + 50% FYM) and control] in main plot, and 3 promis ing rice varieties [‘Shahsarang 1’, ‘Lumpnah’ and ‘Megha’ Semi-Aromatic 2'] in subplots. The results showed that rice grain yield was significantly higher in INM practice, followed by inorganic and organic practice. Among the va rieties, grain yield was significantly higher in ‘Shahsarang 1’ followed by ‘Lumpnah’ and ‘Megha’ SA 2. The INM practice also resulted in highest Fe, Mn, Cu content in rice grains, while the organic practice showed the highest grain Zn. Among the varieties, ‘Megha SA 2’ had highest grain Fe, Mn and Zn content, while ‘Shahsarang 1’ ex hibited the highest grain Cu. Micronutrient uptake in rice grains followed the similar trend as that of nutrient-man agement practices and rice varieties. There was an improvement in available NPK over initial status with higher available NPK in INM practice and higher soil organic carbon in organic practice.