Inherent flexibility of CLIC6 revealed by crystallographic and solution studies
A Ferofontov, R Strulovich, M Marom, M Giladi… - Scientific reports, 2018 - nature.com
Chloride intracellular channels (CLICs) are a family of unique proteins, that were suggested
to adopt both soluble and membrane-associated forms. Moreover, following this unusual
metamorphic change, CLICs were shown to incorporate into membranes and mediate ion
conduction in vitro, suggesting multimerization upon membrane insertion. Here, we present
a 1.8 Å resolution crystal structure of the CLIC domain of mouse CLIC6 (mCLIC6). The
structure reveals a monomeric arrangement and shows a high degree of structural …
to adopt both soluble and membrane-associated forms. Moreover, following this unusual
metamorphic change, CLICs were shown to incorporate into membranes and mediate ion
conduction in vitro, suggesting multimerization upon membrane insertion. Here, we present
a 1.8 Å resolution crystal structure of the CLIC domain of mouse CLIC6 (mCLIC6). The
structure reveals a monomeric arrangement and shows a high degree of structural …
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