Inhibition of platelet-derived growth factor pathway suppresses tubulointerstitial injury in renal congestion
T Matsuki, T Hirose, Y Ohsaki, S Shimada… - Journal of …, 2022 - journals.lww.com
T Matsuki, T Hirose, Y Ohsaki, S Shimada, A Endo, H Ito, C Takahashi, S Yamakoshi…
Journal of Hypertension, 2022•journals.lww.comObjective: Increased central venous pressure in congestive heart failure is responsible for
renal dysfunction, which is mediated by renal venous congestion. Pericyte detachment from
capillaries after renal congestion might trigger renal fibrogenesis via pericyte-myofibroblast
transition (PMT). Platelet-derived growth factor receptors (PDGFRs), which are PMT
indicators, were upregulated in our recently established renal congestion model. This study
was designed to determine whether inhibition of the PDGFR pathway could suppress …
renal dysfunction, which is mediated by renal venous congestion. Pericyte detachment from
capillaries after renal congestion might trigger renal fibrogenesis via pericyte-myofibroblast
transition (PMT). Platelet-derived growth factor receptors (PDGFRs), which are PMT
indicators, were upregulated in our recently established renal congestion model. This study
was designed to determine whether inhibition of the PDGFR pathway could suppress …
Abstract
Objective:
Increased central venous pressure in congestive heart failure is responsible for renal dysfunction, which is mediated by renal venous congestion. Pericyte detachment from capillaries after renal congestion might trigger renal fibrogenesis via pericyte-myofibroblast transition (PMT). Platelet-derived growth factor receptors (PDGFRs), which are PMT indicators, were upregulated in our recently established renal congestion model. This study was designed to determine whether inhibition of the PDGFR pathway could suppress tubulointerstitial injury after renal congestion.
Methods:
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