Inhibition of the Wnt/b-catenin pathway using PNU-74654 reduces tumor growth in in vitro and in vivo models of colorectal cancer
Background Colorectal-cancer (CRC) is amongst the most lethal-cancers, mainly due to its
metastatic spread and drug chemoresistance. Hence there is a need for new approaches to
either increase the efficacy of current therapy or introduce new therapies that have greater
efficacy. There is increasing evidence that dysregulation of WNT-signaling-pathway plays an
essential role in the development and prognosis of CRC. Here we have investigated the
therapeutic potential of targeting the WNT/b-catenin pathway using a novel Wnt/b-catenin …
metastatic spread and drug chemoresistance. Hence there is a need for new approaches to
either increase the efficacy of current therapy or introduce new therapies that have greater
efficacy. There is increasing evidence that dysregulation of WNT-signaling-pathway plays an
essential role in the development and prognosis of CRC. Here we have investigated the
therapeutic potential of targeting the WNT/b-catenin pathway using a novel Wnt/b-catenin …
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