[HTML][HTML] Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells
The mevalonate pathway provides metabolites for post-translational modifications such as
farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently
occurring regulatory processes can induce an aberrant stimulation of DNA
methyltransferase (DNMT1) as well as changes in histone deacetylases (HDACs) and
microRNAs in many cancer cell lines. Inhibitors of the mevalonate pathway are increasingly
recognized as anticancer drugs. Extensive evidence indicates an intense cross-talk between …
farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently
occurring regulatory processes can induce an aberrant stimulation of DNA
methyltransferase (DNMT1) as well as changes in histone deacetylases (HDACs) and
microRNAs in many cancer cell lines. Inhibitors of the mevalonate pathway are increasingly
recognized as anticancer drugs. Extensive evidence indicates an intense cross-talk between …
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