Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1
Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer
and pathogen chronicity. However, the mechanisms that underpin the development of these
regulatory cells, especially in the context of ongoing antigen exposure, have remained
obscure. To address this knowledge gap, we undertook a comprehensive functional,
phenotypic, and transcriptomic analysis of interleukin (IL)-10-producing CD4+ T cells
induced by chronic infection with murine cytomegalovirus (MCMV). We identified these cells …
and pathogen chronicity. However, the mechanisms that underpin the development of these
regulatory cells, especially in the context of ongoing antigen exposure, have remained
obscure. To address this knowledge gap, we undertook a comprehensive functional,
phenotypic, and transcriptomic analysis of interleukin (IL)-10-producing CD4+ T cells
induced by chronic infection with murine cytomegalovirus (MCMV). We identified these cells …
[PDF][PDF] Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1
Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer
and pathogen chronicity. However, the mechanisms that underpin the development of these
regulatory cells, especially in the context of ongoing antigen exposure, have remained
obscure. To address this knowledge gap, we undertook a comprehensive functional,
phenotypic, and transcriptomic analysis of interleukin (IL)-10-producing CD4+ T cells
induced by chronic infection with murine cytomegalovirus (MCMV). We identified these cells …
and pathogen chronicity. However, the mechanisms that underpin the development of these
regulatory cells, especially in the context of ongoing antigen exposure, have remained
obscure. To address this knowledge gap, we undertook a comprehensive functional,
phenotypic, and transcriptomic analysis of interleukin (IL)-10-producing CD4+ T cells
induced by chronic infection with murine cytomegalovirus (MCMV). We identified these cells …
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