Although diabetes results in part from a deficiency of normal pancreatic beta cells, inducing
human beta cells to regenerate is difficult. Reasoning that insulinomas hold the “genomic
recipe” for beta cell expansion, we surveyed 38 human insulinomas to obtain insights into
therapeutic pathways for beta cell regeneration. An integrative analysis of whole-exome and
RNA-sequencing data was employed to extensively characterize the genomic and
molecular landscape of insulinomas relative to normal beta cells. Here, we show at the …