Cholesteryl ester transfer protein (CETP) mediates cholesteryl ester (CE) transfer from the
atheroprotective high density lipoprotein (HDL) cholesterol to the atherogenic low density
lipoprotein cholesterol. In the past decade, this property has driven the development of
CETP inhibitors, which have been evaluated in large scale clinical trials for treating
cardiovascular diseases. Despite the pharmacological interest, little is known about the
fundamental mechanism of CETP in CE transfer. Recent electron microscopy (EM) …