This paper describes an application of artificial neural networks (ANNs) to the prediction of local losses from integrated emitters. First, the optimum input-output combination was determined. Then, the mapping capability of ANNs and regression models was compared. Afterwards, a five-input ANN model, which considers pipe and emitter internal diameter, emitter length, emitter spacing, and pipe discharge, was used to develop a local losses predicting tool which was obtained from different training strategies while taking into account a completely independent test set. Finally, a performance index was evaluated for the test emitter models studied. Emitter data with low reliability were removed from the process. Performance indexes over 80% were obtained for the remaining test emitters.