The world of education is currently growing, demanding very fast and significant changes in various fields including education. The learning model itself is learning that does not only involve technology in it. But rather to change the paradigm that students are not passive objects who must be able to use technology alone. This demand is certainly not an easy thing for teachers to fulfill. The current learning process is expected to be able to form students who have soft skills to face the 21st century, known as 4C (Communication, Collaboration, Critical thinking and Problem Solving, and Creativity and Innovation). This study aims to explain how to integrate 4Cs Skills into Learning by Using the Project Based Learning (PjBL) Model to Face the Challenges of the 21st Century. The PjBL model is one model that can bridge the achievement of 4Cs Skills in learning. In PjBL, students go through a broader process of inquiry to respond to complex questions, problems, or challenges.