Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma

Z Bakouny, DA Braun, SA Shukla, W Pan, X Gao… - Nature …, 2021 - nature.com
… In conclusion, our findings suggest that sarcomatoid and rhabdoid renal cell carcinoma
tumors have distinctive genomic and transcriptomic features that may account for their …

Integrative Molecular Characterization of Sarcomatoid and Rhabdoid Renal Cell Carcinoma Reveals Determinants of Poor Prognosis and Response to Immune …

Z Bakouny, DA Braun, SA Shukla, W Pan, X Gao… - bioRxiv, 2020 - biorxiv.org
… In conclusion, our findings suggest that sarcomatoid and rhabdoid renal cell carcinoma
tumors have distinctive genomic and transcriptomic features that may account for their …

Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma (S/R RCC) to reveal potential determinants of poor prognosis and response to …

Z Bakouny, DA Braun, SA Shukla, W Pan, X Gao… - 2020 - ascopubs.org
… have suggested that these tumors respond well to ICI. Our aim was to perform integrative
molecular characterization of S/R RCC tumors in order to characterize potential features that …

Characterizing sarcomatoid and rhabdoid RCC

L Stone - Nature Reviews Urology, 2021 - nature.com
… an integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma
(… revealed that these tumours harbour distinctive molecular features, display an immune-…

[HTML][HTML] Intratumoral morphologic and molecular heterogeneity of rhabdoid renal cell carcinoma: challenges for personalized therapy

RR Singh, P Murugan, LR Patel, H Voicu, SY Yoo… - Modern Pathology, 2015 - Elsevier
… reads were visualized using Integrative Genomics Viewer. An in… compare the sarcomatoid
and rhabdoid histologies where we … analysis of the biphasic components of rhabdoid clear-cell

The significance of sarcomatoid and rhabdoid dedifferentiation in renal cell carcinoma

AW Hahn, J Lebenthal, G Genovese, K Sircar… - Cancer Treatment and …, 2022 - Elsevier
… While the molecular characterization of rhabdoid dedifferentiation is limited, the available …
with rhabdoid dedifferentiation may derive particular benefit from ICT, similar to sarcomatoid

Stratification of Patients with Renal Cell Carcinoma by the Abundance of Sarcomatoid Features Reveals Differences in Survival and the Underlying Pathobiology

NJ Salgia, WM Aubrecht, L Wang, B Ram… - European Urology …, 2024 - Elsevier
Tumor microenvironment Sarcomatoid renal cell carcinoma (sRCC) is among the most
lethal genitourinary malignancies [1]. Sarcomatoid features are defined by pathognomonic …

Molecular genetics of renal cell tumors: A practical diagnostic approach

R Alaghehbandan, D Perez Montiel, AS Luis, O Hes - Cancers, 2019 - mdpi.com
… or cribriform pattern with rhabdoid-like cell morphology in a myxoid… Molecular characterization
of renal cell neoplasms has led to … [175] developed and examined an integrative genomics …

Treatment outcomes in patients with metastatic renal cell carcinoma with sarcomatoid and/or rhabdoid dedifferentiation after progression on immune checkpoint …

AW Hahn, DS Surasi, PV Viscuse, TK Bathala… - The …, 2024 - academic.oup.com
… and sarcomatoid, rhabdoid, or sarcomatoid plus rhabdoid … at the University of Texas MD
Anderson Cancer Center (MDACC) … for “sarcomatoid” or “rhabdoid” and “renal cell carcinoma,” …

Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma

T El Zarif, K Semaan, M Eid, JH Seo, S Garinet… - Cell Reports, 2024 - cell.com
Renal cell carcinoma with sarcomatoid differentiation (sRCC) is associated with poor survival
and a heightened response to immune checkpoint inhibitors (ICIs). Two major barriers to …