In neurons, spike timing is determined by integration of synaptic potentials in delicate
concert with intrinsic properties. Although the integration time is functionally crucial, it
remains elusive during network activity. While mechanisms of rapid processing are well
documented in sensory systems, agility in motor systems has received little attention. Here
we analyze how intense synaptic activity affects integration time in spinal motoneurons
during functional motor activity and report a 10-fold decrease. As a result, action potentials …

Tau from MLE during ON-cycle. We estimated the membrane time-constants using the
Maximum Likelihood estimation (MLE) procedure in addition to using the auto-correlation
relaxation fitting (figure 4F). The results for both procedures during ON-cycles are plotted
together for comparison in Figure S1. The horizontal lines are the population mean for the
MLE and the autocorrelation exponential fit, respectively. The MLE values are roughly 1
order of magnitude larger than the autocorrelation fitting values. The mean value of the …