Interaction of arylpiperazine ligands with the hydrophobic part of the 5-HT1A receptor binding site
MV Zlatović, VV Šukalović, C Schneider… - Bioorganic & medicinal …, 2006 - Elsevier
MV Zlatović, VV Šukalović, C Schneider, GM Roglić
Bioorganic & medicinal chemistry, 2006•ElsevierA flexible docking of a series of arylpiperazine derivatives with structurally different aryl part
to the binding site of a model of human 5-HT1A receptor was exercised. The influence of
structure and hydrophobic properties of aryl moiety on binding affinities was discussed and
a model for ligand binding in the hydrophobic part of the binding site was proposed.
to the binding site of a model of human 5-HT1A receptor was exercised. The influence of
structure and hydrophobic properties of aryl moiety on binding affinities was discussed and
a model for ligand binding in the hydrophobic part of the binding site was proposed.
A flexible docking of a series of arylpiperazine derivatives with structurally different aryl part to the binding site of a model of human 5-HT1A receptor was exercised. The influence of structure and hydrophobic properties of aryl moiety on binding affinities was discussed and a model for ligand binding in the hydrophobic part of the binding site was proposed.
Elsevier
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