Rotaviruses are members of the Reoviridae family of non-enveloped viruses and important
etiologic agents of acute gastroenteritis in infants and young children. In recent years, high-
resolution structures of triple-layered rotavirus virions and the constituent proteins have
provided valuable insights into functions. Of note, structural studies have revealed the
position of the viral RNA-dependent RNA polymerase, VP1, within the inner capsid, which in
turn provides clues about the location of the viral capping machinery and the route of viral …