Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by
the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H. Although the
loss of these dependence receptors' expression has been described as a selective
advantage for tumor growth and progression in numerous cancers, recent observations
have shown that some tumors may use an alternative strategy to block dependence receptor-
induced programmed cell death: the autocrine expression of netrin-1. This alternative …

Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by
the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H. While a loss of
these dependence receptors expression has been described as a selective advantage'for
tumor growth and progression in numerous cancers, recent observations have shown that
some tumors may utilize an alternative strategy to block dependence receptor-induced
programmed cell death: the autocrine expression of netrin-1. This alternative strategy has …