Interleukin-23 deficiency leads to impaired wound healing and adverse prognosis after myocardial infarction
K Savvatis, K Pappritz, PM Becher… - Circulation: Heart …, 2014 - Am Heart Assoc
Background—CD4+ cells are implicated in the healing process after myocardial infarction
(MI). We sought to investigate the role of interleukin-23 (IL-23) deficiency, a cytokine
important in differentiation of CD4+ cells, in scar formation of the ischemic heart. Methods
and Results—MI was performed in wild-type and IL23p19−/− mice. Thirty-day mortality,
hemodynamic function 4 days after MI and myocardial inflammation, and remodeling 4 and
30 days after MI were examined. Differentiation of fibroblasts from infarcted and noninfarcted …
(MI). We sought to investigate the role of interleukin-23 (IL-23) deficiency, a cytokine
important in differentiation of CD4+ cells, in scar formation of the ischemic heart. Methods
and Results—MI was performed in wild-type and IL23p19−/− mice. Thirty-day mortality,
hemodynamic function 4 days after MI and myocardial inflammation, and remodeling 4 and
30 days after MI were examined. Differentiation of fibroblasts from infarcted and noninfarcted …
以上显示的是最相近的搜索结果。 查看全部搜索结果