IL-6 is a multifunctional proinflammatory cytokine that is elevated in the serum of patients
with pulmonary arterial hypertension (PAH) and can predict the survival of patients with
idiopathic PAH (IPAH). Previous animal experiments and clinical human studies indicate
that IL-6 is important in PAH; however, the molecular mechanisms of IL-6–mediated
pathogenesis of PAH have been elusive. Here we identified IL-21 as a downstream target of
IL-6 signaling in PAH. First, we found that IL-6 blockade by the monoclonal anti-IL-6 receptor …

CiNii 博士論文 - Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of
pulmonary arterial hypertension … Interleukin-6/interleukin-21 signaling axis is critical in
the pathogenesis of pulmonary arterial hypertension インターロイキン6/インターロイキン21シグナル軸は
肺動脈性肺高血圧症の病態形成に重要である … Interleukin-6/interleukin-21 signaling axis is
critical in the pathogenesis of pulmonary arterial hypertension …