Background: Hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma
(HCC). Cytokines play an important role in the regulation of immune responses and defense
against viral infections. Human interleukin 6 (IL6) is a multifunctional cytokine that
participates in these processes. Objective: The aim of this study was to assess the IL6-174
gene polymorphism in patients with chronic hepatitis B virus (HBV) infection as compared
with healthy controls in an Iranian population. Materials and Methods: Totals of 297 HBV …

Hepatitis B virus infection is a significant risk factor for cirrhosis and hepatocellular
carcinoma. Interleukin-6, a cytokine with broad pleiotropic actions, plays important role in
cellular and humoral immune responses to viral infection. The-174 G/C polymorphisms of
interleukin-6 is a frequent polymorphism and may determine the outcome of viral infection.
To find out the genetic association between the-174 G/C polymorphism and susceptibility to
hepatitis B virus infection in Javanese individuals, blood samples from Javanese hepatitis B …