Intermolecular Detergent–Membrane Protein NOEs for the Characterization of the Dynamics of Membrane Protein–Detergent Complexes
C Eichmann, J Orts, C Tzitzilonis… - The Journal of …, 2014 - ACS Publications
The interaction between membrane proteins and lipids or lipid mimetics such as detergents
is key for the three-dimensional structure and dynamics of membrane proteins. In NMR-
based structural studies of membrane proteins, qualitative analysis of intermolecular nuclear
Overhauser enhancements (NOEs) or paramagnetic resonance enhancement are used in
general to identify the transmembrane segments of a membrane protein. Here, we employed
a quantitative characterization of intermolecular NOEs between 1H of the detergent and …
is key for the three-dimensional structure and dynamics of membrane proteins. In NMR-
based structural studies of membrane proteins, qualitative analysis of intermolecular nuclear
Overhauser enhancements (NOEs) or paramagnetic resonance enhancement are used in
general to identify the transmembrane segments of a membrane protein. Here, we employed
a quantitative characterization of intermolecular NOEs between 1H of the detergent and …
[引用][C] Intermolecular Detergent–Membrane Protein NOEs for the Characterization of the Dynamics of Membrane Protein–Detergent Complexes
E Cédric, O Julien, T Christos, V Beat, S Sean, L Justin… - 2014