… RAx application for regulatory purposes in … read-across (ECHA RAAF), facing the issue
of regulatory acceptance from the point of view of the registrants of NAM-supported read-across …

… assessment by using data from alternative methods. The CS were run under 2 conditions:
read-across without additional new approach data; addition of NAM data (primarily from …

… the widespread application of read-across are (1) insufficient documentation of validation,
(2… and variability in read-across when integrated with new approach methodologies. There is a …

… New approach methodologies, such as in vitro assays and in silico models, have great
potential to strengthen read-across … (also for regulatory purposes), and integration of NAM data …

… strategy for read-across (RAx) as an animal-free approach in chemical … on the regulatory
implementation of new approaches. … and pre-validation of the EU-ToxRisk NAM toolbox is a step …

… and read-across for chemicals. Although read-across is not explicitly prohibited in the process
… Nonetheless, a scientifically justified read-across of material-based endpoints, as well as …

… The approach taken demonstrates how software implementing … read-across can support
decisions and how validation of the methods can increase confidence in the overall approach. …

… in a new framework to provide validation of NAMs, in assessments such as read across, as
… We chose the current REACH regulatory guidelines to be the setting for our investigation, …

… a regulatory context, but as yet no formalised process exists … from which a reliable read-across
prediction can be made. … and / or in vitro New Approach Methodology (NAM) data may …

… Changes in the regulatory landscape of chemical safety assessment call for the use of New
Approach Methodologies (NAMs) including read-across to fill data gaps. One critical aspect …