Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts
JA Giménez-Bastida, M Larrosa… - Journal of Agricultural …, 2012 - ACS Publications
Pomegranate ellagitannins (ETs) are transformed in the gut to ellagic acid (EA) and its
microbiota metabolites, urolithin A (Uro-A) and urolithin B (Uro-B). These compounds exert
anti-inflammatory effects in vitro and in vivo. The aim of this study was to investigate the
effects of Uro-A, Uro-B, and EA on colon fibroblasts, cells that play a key role in intestinal
inflammation. CCD18-Co colon fibroblasts were exposed to a mixture of Uro-A, Uro-B, and
EA, at concentrations comparable to those found in the colon (40 μM Uro-A, 5 μM Uro-B, 1 …
microbiota metabolites, urolithin A (Uro-A) and urolithin B (Uro-B). These compounds exert
anti-inflammatory effects in vitro and in vivo. The aim of this study was to investigate the
effects of Uro-A, Uro-B, and EA on colon fibroblasts, cells that play a key role in intestinal
inflammation. CCD18-Co colon fibroblasts were exposed to a mixture of Uro-A, Uro-B, and
EA, at concentrations comparable to those found in the colon (40 μM Uro-A, 5 μM Uro-B, 1 …
[引用][C] Intestinal Ellagitannin Metabolites Ameliorate Cytokine-Induced Inflammation and Associated Molecular Markers in Human Colon Fibroblasts
L Mar, GS Antonio, TB Francisco, GC María-Teresa - 2012
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