To investigate the prevalence of and co-infectivity paradigm of parasitic opportunistic infections and their demographics among HIV positive individuals. Case study of 100 individuals screened for HIV 1 and 2 antibodies using the Enzyme Linked Immunosobent Assay (ELISA) at two major HIV Referral Centres in Nsukka was undertaken. Fifty of the HIV seropositive persons were screened for intestinal parasites using the Formol-ether concentration technique. Data was collected on pre-designed proforms and analysed using SPSS 17.0 (Chicago, USA). Gender profile of HIV infection indicated preponderance among the females (66%). Co-infection of HIV and parasitic infections was established: prevalence was significant among different occupational groups; highest among drivers and traders (100%), with no age difference or bias (P<0.001). Implicated risk factors included ignorance/illiteracy, poor sources of potable-water and unhygienic lifestyle including indiscriminate disposal of sewage and domestic wastes (P<0.05). The most predominant debilitating parasitic infections among the dually infected were Ascaris lumbricoides (28%) and hookworm (20%). No significant difference was observed in the rate of infection by Trichuris trichuria (4%) and Giardia limbia (4%). Prevalence of, and public health importance of parasitic infections as serious AIDS-defining condition which need urgent attention in the rural communities of Nigeria is here underscored. The study further advocates the incorporation of stringent screening for intestinal parasites in the management of people living with HIV/AIDS in resource poor communities of Nigeria and the entire sub-Saharan Africa where poverty and poor living standards predispose to severe coinfection of HIV and parasitic opportunistic pathogens.