Intestinal-derived HDL: The portal guardian of the liver

S Chen, D Wang - Immunity, 2021 - cell.com
S Chen, D Wang
Immunity, 2021cell.com
The trafficking and function of intestine-derived high-density lipoprotein (HDL) have not
been identified. In a recent issue of Science, Han et al.(2021) find that intestine-derived HDL
neutralizes intestinal-leaked LPS in the portal vein, serving as a host disease tolerance
strategy to restrain liver damage of enteric origin under physiological conditions.
The trafficking and function of intestine-derived high-density lipoprotein (HDL) have not been identified. In a recent issue of Science, Han et al. (2021) find that intestine-derived HDL neutralizes intestinal-leaked LPS in the portal vein, serving as a host disease tolerance strategy to restrain liver damage of enteric origin under physiological conditions.
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