Intracellular degradable hydrogel cubes and spheres for anti-cancer drug delivery
Shape and responsiveness of nanoengineered delivery carriers are crucial characteristics
for rapid and efficient delivery of therapeutics. We report on a novel type of micrometer-sized
hydrogel particles of controlled shape with dual pH-and redox-sensitivity for intracellular
delivery of anticancer drugs. The cubical and spherical poly (methacrylic acid)(PMAA)
networks with disulfide links are obtained by cross-linking PMAA with cystamine within
hydrogen-bonded multilayers of PMAA/poly (vinylpyrrolidone)(PMAA/PVPON) on sacrificial …
for rapid and efficient delivery of therapeutics. We report on a novel type of micrometer-sized
hydrogel particles of controlled shape with dual pH-and redox-sensitivity for intracellular
delivery of anticancer drugs. The cubical and spherical poly (methacrylic acid)(PMAA)
networks with disulfide links are obtained by cross-linking PMAA with cystamine within
hydrogen-bonded multilayers of PMAA/poly (vinylpyrrolidone)(PMAA/PVPON) on sacrificial …
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