Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins
Hydrogen peroxide (H2O2) accumulates transiently in various cell types stimulated with
peptide growth factors and participates in receptor signaling by oxidizing the essential
cysteine residues of protein tyrosine phosphatases and the lipid phosphatase PTEN. The
reversible inactivation of these phosphatases by H2O2 is likely required to prevent futile
cycles of phosphorylation–dephosphorylation of proteins and phosphoinositides. The
accumulation of H2O2 is possible even in the presence of large amounts of the antioxidant …
peptide growth factors and participates in receptor signaling by oxidizing the essential
cysteine residues of protein tyrosine phosphatases and the lipid phosphatase PTEN. The
reversible inactivation of these phosphatases by H2O2 is likely required to prevent futile
cycles of phosphorylation–dephosphorylation of proteins and phosphoinositides. The
accumulation of H2O2 is possible even in the presence of large amounts of the antioxidant …
[引用][C] Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins
R SG - Curr Opin Cell Biol, 2005 - cir.nii.ac.jp
Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins |
CiNii Research … Intracellular messenger function of hydrogen peroxide and its regulation
by peroxiredoxins …
CiNii Research … Intracellular messenger function of hydrogen peroxide and its regulation
by peroxiredoxins …
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