Intracellular pH and activation of sea urchin eggs after fertilisation
… It is this hydrogen efflux, with the resultant change in intracellular pH, and not the sodium
influx, that is the prerequisite for metabolic activation. We suggest that the suppression of
metabolism of the unfertilised egg is a result of maintaining a low intracellular pH and that the
rapid effux of hydrogen ions after fertilisation by way of the sodium-coupled exchange raises
the intracellular pH. This change allows the increased metabolism referred to as egg activation. …
influx, that is the prerequisite for metabolic activation. We suggest that the suppression of
metabolism of the unfertilised egg is a result of maintaining a low intracellular pH and that the
rapid effux of hydrogen ions after fertilisation by way of the sodium-coupled exchange raises
the intracellular pH. This change allows the increased metabolism referred to as egg activation. …
Abstract
The intracellular pH of the sea urchin embryo increases 0.3 pH units between 1 and 4 min after fertilisation. The increase in pH is required for initiating development. The increase results from an exchange of extracellular Na+ for intracellular H+.
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