The aim of this study was to evaluate the response of treatment of central giant cell lesion to intralesional corticosteroid injections. Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and development of a descriptive meta-analysis of the results. Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a male female ratio of 1: 0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result, 14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Considering the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections. In view of the results analyzed, intralesional corticosteroid injections could be considered as first treatment option for central giant cell lesion.