[HTML][HTML] Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques
N van Doremalen, JN Purushotham, JE Schulz… - BioRxiv, 2021 - ncbi.nlm.nih.gov
Intramuscular vaccination with ChAdOx1 nCoV-19/AZD1222 protected rhesus macaques
against pneumonia but did not reduce shedding of SARS-CoV-2. Here we investigate
whether intranasally administered ChAdOx1 nCoV-19 reduces shedding, using a SARS-
CoV-2 virus with the D614G mutation in the spike protein. Viral load in swabs obtained from
intranasally vaccinated hamsters was significantly decreased compared to controls and no
viral RNA or infectious virus was found in lung tissue, both in a direct challenge and a …
against pneumonia but did not reduce shedding of SARS-CoV-2. Here we investigate
whether intranasally administered ChAdOx1 nCoV-19 reduces shedding, using a SARS-
CoV-2 virus with the D614G mutation in the spike protein. Viral load in swabs obtained from
intranasally vaccinated hamsters was significantly decreased compared to controls and no
viral RNA or infectious virus was found in lung tissue, both in a direct challenge and a …
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