▪ Abstract The kidney regulates sodium metabolism with extraordinary precision and
sensitivity. This is accomplished by an intricate interaction between signals from extrarenal
and intrarenal sources and between anti-natriuretic and natriuretic factors. Dopamine,
produced in renal proximal tubule cells, plays a central role in this interactive network.
Natriuretic hormones that are released from extrarenal sources, such as atrial natriuretic
peptide, mediate some of their effects via renal dopamine receptors. On the level of the …