Intravenous doxycycline, azithromycin, or both for severe scrub typhus

GM Varghese, D Dayanand… - … England Journal of …, 2023 - Mass Medical Soc
severe scrub typhus, we found that combination therapy with intravenous doxycycline and
azithromycin … day 7, and persistent fever at day 5 in both the modified intention-to-treat and per-…

[HTML][HTML] INTRAVENOUS DOXYCYCLINE OR AZITHROMYCIN OR A COMBINATION OF THE TWO FOR TREATMENT OF SEVERE SCRUB TYPHUS: A …

G Varghese, D Dayanand, K Gunasekaran… - International Journal of …, 2023 - Elsevier
intravenous azithromycin, doxycycline, or a combination of both in treating severe scrub
typhus… Patients older than 15-years with severe scrub typhus with at least one organ involvement …

Doxycycline vs azithromycin in patients with scrub typhus: a systematic review of literature and meta-analysis

N Gupta, C Boodman, CG Jouego… - BMC Infectious …, 2023 - Springer
… of both drugs except for the two studies on severe scrub typhus, where intravenous … In
certain regions where the availability of intravenous doxycycline is limited, advocating for …

Outcome of intravenous azithromycin therapy in patients with complicated scrub typhus compared with that of doxycycline therapy using propensity-matched analysis

MO Jang, HC Jang, UJ Kim, JH Ahn… - Antimicrobial agents …, 2014 - Am Soc Microbiol
… was defined as scrub typhus related if there was no other definite … severe scrub typhus (10).
In this study, we showed that the efficacy of azithromycin is comparable to that of doxycycline

Clinical outcomes of doxycycline, azithromycin and chloramphenicol for the treatment of patients with severe scrub typhus

XG Guan, SX Zhou, AR Zhang, QB Lu, ZW Zhou… - International Journal of …, 2022 - Elsevier
… or dyspnoea; (2) acute kidney injury, defined as a two-fold increase in serum creatinine or an
… (500 mg orally/intravenously every 24 h) or chloramphenicol (2 g orally/intravenously every …

Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis

SC Lee, YJ Cheng, CH Lin, WT Lei, HY Chang… - Medicine, 2017 - journals.lww.com
… Oral azithromycin was used in 3 studies, and intravenous … of scrub typhus to some antibiotics,
including doxycycline and … Our study suggests that azithromycin is as effective as other

[HTML][HTML] Treatment outcomes of oral doxycycline versus intravenous azithromycin in adults hospitalized with scrub typhus: A retrospective study using inverse …

JH Hwang, MJ Kim, YJ Im, SJ Moon, JH Kim… - Travel Medicine and …, 2023 - Elsevier
… to doxycycline for the treatment of scrub typhus [6]. Azithromycin is available in both oral
and intravenous formulations and both are used in patients with scrub typhus. In a recent meta-…

[PDF][PDF] Comparison of therapeutic effect of azithromycin against doxycycline in scrub typhus: systematic review and meta-analysis

SC Sharda, MS Bhatia - infectiousjournal.com
… with both azithromycin and doxycycline, suggesting that both medications … intravenous
azithromycin therapy in patients with complicated scrub typhus compared with that of doxycycline

[HTML][HTML] Antibiotic combination therapy for severe scrub typhus: is it necessary?

MH Chung, JS Lee, JH Im - Infection & Chemotherapy, 2023 - ncbi.nlm.nih.gov
… of scrub typhus and the limitations of the combination of doxycycline and azithromycin. … trials
are needed for the two-drug combinations of doxycycline, azithromycin, and rifampin, unless …

Efficacy and safety of antibiotics for treatment of scrub typhus: a network meta-analysis

J Yang, L Luo, T Chen, L Li, X Xu, Y Zhang… - JAMA Network …, 2020 - jamanetwork.com
… the wide use of doxycycline, azithromycin, tetracycline, and chloramphenicol for treating …
So far, these 4 antibiotics do not display better efficacy or safety than other antibiotics, which …