Intravital imaging reveals angiotensin II–induced transcytosis of albumin by podocytes
IM Schießl, A Hammer, V Kattler, B Gess… - Journal of the …, 2016 - journals.lww.com
Albuminuria is a hallmark of kidney disease of various etiologies and usually caused by
deterioration of glomerular filtration barrier integrity. We recently showed that angiotensin II
(Ang II) acutely increases albumin filtration in the healthy kidney. Here, we used intravital
microscopy to assess the effects of Ang II on podocyte function in rats. Acute infusion of 30,
60, or 80 ng/kg per minute Ang II enhanced the endocytosis of albumin by activation of the
type 1 Ang II receptor and resulted in an average (±SEM) of 3.7±2.2, 72.3±18.6 (P< 0.001) …
deterioration of glomerular filtration barrier integrity. We recently showed that angiotensin II
(Ang II) acutely increases albumin filtration in the healthy kidney. Here, we used intravital
microscopy to assess the effects of Ang II on podocyte function in rats. Acute infusion of 30,
60, or 80 ng/kg per minute Ang II enhanced the endocytosis of albumin by activation of the
type 1 Ang II receptor and resulted in an average (±SEM) of 3.7±2.2, 72.3±18.6 (P< 0.001) …
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