Intravitreal aflibercept partially reverses severe non-proliferative diabetic retinopathy in treatment-naive patients

Y Tao, P Jiang, M Liu, Y Liu, L Song… - Journal of International …, 2021 - journals.sagepub.com
… be reversed after aflibercept treatment based on changes in diabetic macular edema, HEs …
alleviation of leakage due to reperfusion in the non-perfusion area, but we cannot rule out the …

Disentangling the association between retinal non-perfusion and anti-VEGF agents in diabetic retinopathy

I Chatziralli, S Touhami, MV Cicinelli, C Agapitou… - Eye, 2022 - nature.com
… with PDR treated with intravitreal 2.0 mg aflibercept either monthly or quarterly, showed
stability in the amount of non-perfusion in patients receiving monthly aflibercept and not in those …

Retinal non-perfusion in diabetic retinopathy

CC Wykoff, HJ Yu, RL Avery, JP Ehlers, R Tadayoni… - Eye, 2022 - nature.com
retinal non-perfusion (RNP) are a key pathologic feature of the vascular component of diabetic
retinopathy. … of Intravitreal Aflibercept Injection for Improvement of Retinal Nonperfusion in …

Final outcomes from the randomized RECOVERY trial of aflibercept for retinal nonperfusion in proliferative diabetic retinopathy

CC Wykoff, MG Nittala, CV Boone, JY Hannah… - … Retina, 2022 - Elsevier
… , randomized RECOVERY (Intravitreal Aflibercept for Retinal Nonperfusion in
Proliferative Diabetic Retinopathy) trial was to evaluate the impact of intravitreal aflibercept (Eylea, …

Effect of Aflibercept on macular retinal layers and peripheral non perfusion in subjects with Proliferative Diabetic retinopathy

SB Velaga - 2019 - search.proquest.com
… The thickness of multiple retinal sublayers appears to decrease … intravitreal aflibercept
for proliferative diabetic retinopathy despite an absence of a change in peripheral non-perfusion. …

[HTML][HTML] Intravitreal Aflibercept for Retinal Non-Perfusion in Proliferative Diabetic Retinopathy: Primary Outcomes from the RECOVERY Study

MG Nittala, SB Velaga, B Zhou… - … & Visual Science, 2019 - iovs.arvojournals.org
intravitreal aflibercept on retinal non-perfusion (RNP) in eyes with proliferative diabetic
retinopathy (PDR) with no macular … , p<0.001) at month 12 following intravitreal aflibercept. …

Anti‐vascular endothelial growth factor therapy and retinal nonperfusion in diabetic retinopathy: A meta‐analysis of randomised trials

K Nanji, GS Sarohia, J Xie, NS Patil… - Acta …, 2024 - Wiley Online Library
Retinal non-perfusion (RNP) is fundamental to disease onset and progression in diabetic
retinopathy (DR). … Three studies utilised ranibizumab, 2 studies utilised aflibercept and 1 study …

Intravitreal aflibercept compared with panretinal photocoagulation for proliferative diabetic retinopathy: the CLARITY non-inferiority RCT

S Sivaprasad, P Hykin, AT Prevost… - Efficacy and …, 2018 - discovery.ucl.ac.uk
… In the mechanistic substudy, we evaluated the changes induced by aflibercept on retinal
new vessels, capillary non-perfusion and retinal intravascular oxygen saturation. …

Efficacy of aflibercept treatment and its effect on the retinal perfusion in the oxygen-induced retinopathy mouse model of retinopathy of prematurity

SM Amin, A Gonzalez, J Guevara, C Bolch… - Ophthalmic …, 2021 - karger.com
… = 35 eyes) of intravitreal aflibercept administered on postnatal … -related macular degeneration,
diabetic retinopathy, macular … in retinal non-perfusion at varying doses of aflibercept in the …

Intravitreal anti-vascular endothelial growth factor agents for the treatment of diabetic retinopathy: a review of the literature

I Chatziralli, A Loewenstein - Pharmaceutics, 2021 - mdpi.com
… -VEGF agents on the regression of retinal non-perfusion in patients with DR. Furthermore, …
In this study, initial treatment with 4-monthly intravitreal aflibercept injections was compared …